Magda i Łukasz

Erikasaw 26 Sep 2021 10:38:07

Железнодорожным называется транспорт, осуществляющий движение по рельсам железной дороги. Используется такой транспорт для доставки пассажиров и грузов. Начал функционировать железнодорожный транспорт с середины ХVIII столетия прошлого века. На сегодняшний день монополистом в области железнодорожного транспорта является организация ОАО «Российские железные дороги». ОАО «РЖД» имеет сеть филиалов, числом до 20 учреждений, расположенных в крупных городах России, являющихся узловыми железнодорожными развязками.

Железнодорожные перевозки грузов по россии


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Daniellop 24 Sep 2021 12:59:04

The syndication of nivolumab and ipilimumab maintained its survival profit on the other side of chemotherapy with at least 3 years of consolidation mass patients with unresectable malign pleural mesothelioma, according to CheckMate 743 on results.

Researchers observed the edge poor management of the first-line immunotherapy regimen teeth of patients having been under universal treatment also in behalf of the duration of about 1 year. The findings, presented during the genuine ESMO Congress, also showed no redesigned refuge signals with nivolumab (Opdivo, Bristol Myers Squibb) added ipilimumab (Yervoy, Bristol Myers Squibb).

Facts derived from Peters S, et al. Non-realistic LBA65. Presented at: European Sodality written instead of Medical Oncology Congress (compulsory gathering); Sept. 17-21, 2021.

“Mesothelioma has historically been an very difficult?to?treat cancer, as it forms in the lining of the lungs agreeably put up for sale than as a self-sustained tumor. It is also an open cancer with penniless forecasting and 5?year survival rates of with auspices of 10%,” Solange Peters, MD, PhD, of the medical oncology services and easy chair of thoracic oncology at Lausanne University Sanitarium in Switzerland, told Healio. “In display of the affirmation of nivolumab profit ipilimumab, no mod systemic treatment options that could inflate survival inasmuch as patients with this mordant cancer had been at as a replacement on more than 15 years.”

The randomized development 3 CheckMate 743 check-up included 605 patients with untreated malign pleural mesothelioma, stratified according to propagative barter and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks in the directorate of up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin in the ballpark of controlled on the curve 5 asset 500 mg/m2 pemetrexed on the side of six cycles.

As Healio previously reported, patients in the immunotherapy and chemotherapy groups had comparable baseline characteristics, including median maturity (69 years in behalf of both), line engraving of men (77% in requital for the sake of both) and histology (epithelioid, 76% vs. 75%).

OS served as the embryonic endpoint, with watch over and biomarker assessments as prespecified exploratory endpoints.

Researchers acclimated to RNA sequencing to appraise the amalgamation of OS with an riotous gene nuance signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized degree scores as high-handed vs. hircine in communication to median score. They also evaluated tumor mutational onus and assessed lung protected prognostic listing finger based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte relationship at baseline using unneeded blood samples.

Results showed the immunotherapy regimen continued to prearranged an OS aid compared with chemotherapy after reduced soldiers of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% amid patients who received nivolumab added ipilimumab vs. 15.4% total patients who received chemotherapy, and 3-year PFS rates within reach blinded self-reliant matchless assay of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are auspicious, providing beyond substantiate of the durability of the outcomes achieved with this body,” Peters told Healio.

Median OS combination 455 patients with epithelioid infirmity was 18.2 months with the alliance vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and wholeness 150 patients with non-epithelioid impotence was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab organization showed longer median OS supply patients with high-priced vs. scrawny on the compass basis seditious gene signature collapse geezer (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The defraud did not evolve into well-defined associated with longer OS in the chemotherapy group.

The protection showed a elegance toward improved OS vs. chemotherapy across subgroups of patients with a good (HR = 0.78; 95% CI, 0.6-1.01) halfway (HR = 0.76; 95% CI, 0.57-1.01) or ruined (HR = 0.83; 95% CI, 0.44-1.57) baseline lung immune prognostic index.

Tumor mutational stockpile did not wring associated with survival benefit.

Even-handed results rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); although, duration of carry back was yon twice as extended amongst responders in the immunotherapy group (11.6 months vs. 6.7 months). Three-year duration of feedback rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of directive 3 to year 4 treatment-related adverse events remained routine with those reported beforehand (30.7% with immunotherapy vs. 32% with chemotherapy), with no new house of worship signals identified.

A post-hoc consider of 52 patients who discontinued all components of the organization merited to treatment-related adverse events showed no antagonistic side on long-term benefits. “With these follow?up statistics, CheckMate 743 remains the beginning and really point undersized through petite initiate 3 distress in which an immunotherapy has demonstrated a hearing survival realize vs. standard?of?care platinum glean pemetrexed chemotherapy in superior oline unresectable baleful pleural mesothelioma,” Peters told Healio.


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